Nitazoxanide (Nizonide) syrup - Uses (Indications), Dosage, Mode of action, Side effects, brand name in Pakistan, use in COVID-19 (COVID study). Last updated on Apr 8, 2020. Check with your doctor immediately if any of the following side effects occur while taking nitazoxanide: Some side effects of nitazoxanide may occur that usually do not need medical attention. Tell your doctor if any of these symptoms are severe or do not go away: stomach pain; headache; upset stomach; vomiting; discolored urine; Some side effects can be serious. Change in color of urine. Call your doctor for medical advice about side effects. If you notice any other effects, check with your healthcare professional. Epub 2020 Feb 27. Antiepileptic treatment was continued. What should I watch for? Fox LM, Saravolatz LD "Nitazoxanide: a new thiazolide antiparasitic agent." A very serious allergic reaction to this drug is rare. If you notice any other effects, check with your healthcare professional. 1. We comply with the HONcode standard for trustworthy health information -, Dwarf Tapeworm Infection (Hymenolepis nana). Nitazoxanide is a light yellow crystalline powder. Nitazoxanide warning Take prescribed dose correctly and not to change the dose or discontinue therapy unless advised by your health care provider. If experienced, these tend to have a Less Severe expression. Gastroesophageal Reflux Disease. vitamins, herbal supplements, etc. Check with your doctor immediately if any of the following side effects occur: Some side effects may occur that usually do not need medical attention. Available for Android and iOS devices. Tablet: Store it at room temperature. Along with its needed effects, a medicine may cause some unwanted effects. Drug information provided by: IBM Micromedex. If you experience any of these symptoms, call your doctor immediately: skin rash; itching; Nitazoxanide may cause other side effects. ), allergies, pre-existing diseases, and current health conditions (e.g. Our general interest e-newsletter keeps you up to date on a wide variety of health topics. Side effects of Generic Alinia (nitazoxanide) Stop taking nitazoxanide and seek emergency medical attention if you experience a rare allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives). Possible serious side effects of nitazoxanide include: Lung disease; Pharyngitis; Fast heart beat; Fainting; Low blood pressure; Painful urination; Painful or no menstruation; Kidney pain; Anemia; Increased white blood cells; Spontaneous bone fracture Stockis A, De Bruyn S, Gengler C, Rosillon D "Nitazoxanide pharmacokinetics and tolerability in man during 7 days dosing with 0.5 g and 1 g b.i.d." However, many people have no side effects or only have minor side effects. Nitazoxanide is well tolerated when administered in the recommended dose, with reported side effects being no different than placebo. to 4 g with minimal gastrointestinal side effects. Gastrointestinal- Abdominal pain, diarrhea, nausea, vomiting. vomiting. In seven patients dexamethasone 8 mg/day in 4 divided doses was given for the first 5-7 days after the start of treatment. Nitazoxanide storage conditions Oral: Suspension: Store it at 15-30°C (59-86°F). Nitazoxanide may cause side effects. This drug usually has no side effects. P l a s m a. concentrations of tizoxanide have demonstrated dose . Wash your hands, scrub your fingernails and shower often. The most common side effects were abdominal pain, headache, chromaturia, and nausea. Along with its needed effects, nitazoxanide may cause some unwanted effects. You may report them to the FDA. ).Some health conditions may make you more susceptible to the side-effects of the drug. It is given by the oral route with good bioavailability and is well tolerated, with primarily mild gastrointestinal side effects. Other, less serious side effects may be more likely to occur. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away: Headache. Visit your doctor or health care professional for a follow-up visit as directed. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Side effects What side effects can occur from Nitazoxanide? Although not all of these side effects may occur, if they do occur they may need medical attention. Read the entire detailed patient monograph for Alinia (Nitazoxanide) Nitazoxanide side effects Central Nervous System- Headache. These side effects may go away during treatment as your body adjusts to the medicine. Epub 2012 Mar 17. Chemically, nitazoxanide is 2-acetyloxy-N-(5-nitro-2-thiazolyl)benzamide. dazole and nitazoxanide ex ert essentially differential effects on G. duoden alis tr ophozoites in vitro, with respect to morpho- logical and ultr astructural alter ations, also suggesting that the A Skin Rash. [Ref], Common (1% to 10%): Abdominal pain, nausea, Frequency not reported: Vomiting, flatulence, dyspepsia, constipation, dry mouth, enlarged salivary glands, Postmarketing reports: Diarrhea, gastroesophageal reflux disease[Ref], Frequency not reported: Somnolence, tremor, hypesthesia, syncope, Frequency not reported: Discolored urine, dysuria, amenorrhea, metrorrhagia, edema labia[Ref], Postmarketing reports: Rash, urticaria[Ref], Frequency not reported: Epistaxis, rhinitis, lung disease, pharyngitis, Frequency not reported: Asthenia, fever, pain, pelvic pain, back pain, influenza syndrome, earache, chills, thirst, infection[Ref], Frequency not reported: Anorexia, increased appetite[Ref], Frequency not reported: Myalgia, leg cramps, spontaneous bone fracture[Ref], Frequency not reported: Tachycardia, hypertension[Ref], Frequency not reported: Anemia, leukocytosis[Ref], Frequency not reported: Kidney pain, increased creatinine[Ref], Frequency not reported: Increased ALT[Ref], Frequency not reported: Allergic reaction[Ref], Frequency not reported: Eye discoloration (including pale yellow eye discoloration)[Ref]. Nitazoxanide suppresses IL-6 production in LPS-stimulated mouse macrophages and TG-injected mice. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Applies to nitazoxanide: oral powder for reconstitution, oral tablet, Side effects were generally mild. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. heartburn. Pharmacology Pharmacodynamics. Nitazoxanide is a light yellow crystalline powder. Nitazoxanide is a new thiazolide antiparasitic agent that shows excellent in vitro activity against a wide variety of protozoa and helminths. pregnancy, upcoming surgery, etc. Mayo Clinic does not endorse companies or products. Oral doses of 4 grams in healthy adults do not appear to cause any significant adverse effects. There is no information about the presence of nitazoxanide in human milk, the effects on the breast-fed infant, or the effects on milk production. You may need to have tests done to check that the infection is cleared. Nitazoxanide side effects. Likewise, there are no data on safety in pregnancy, although reproductive toxicity studies in laboratory animals undertaken by the manufacturer have not revealed any adverse findings. This content does not have an Arabic version. Side Effects of Drugs, Annual 23 J.K. Aronson, ed. Nitazoxanide Use as Part of an Empiric Multi-Drug Regimen in Treating Children with Suspected Helicobacter pylori Infection May 2015 Case Reports in Gastroenterology 9(1):36-42 ([2014, Nov -]): 3. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. You may report side effects to FDA at 1-800-FDA-1088. All rights reserved. Medically reviewed by Drugs.com. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. 500 mg Nitazoxanide taken orally every 12 hours with food for 3 days. Advertising revenue supports our not-for-profit mission. This is not a complete list of side effects and others may occur. Melbourne: Therapeutic Guidelines Limited "eTG complete [Online] Available from: URL: http://online.tg.org.au/complete/desktop/tgc.htm." Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. doxycycline, metronidazole, Flagyl, albendazole, mebendazole, Vibramycin, chloroquine, tinidazole, nitazoxanide, praziquantel. However, get medical help right away if you notice any symptoms of a serious allergic reaction, such as: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, … You may report side effects to FDA at 1-800-FDA-1088. Trouble Breathing. You may report side effects to the FDA at 1-800-FDA-1088. This medication comes as a suspension (liquid) and tablet to take by mouth and is usually taken every 12 hours with food. It is poorly soluble in ethanol and practically insoluble in water. This site complies with the HONcode standard for trustworthy health information: verify here. Adverse events have been mild and transient and principally related to the gastrointestinal tract, such as abdominal pain, diarrhea, and nausea. The side effects of nitazoxanide do not significantly differ from a placebo treatment for giardiasis; these symptoms include stomach pain, headache, upset stomach, vomiting, discolored urine, excessive urinating, skin rash, itching, fever, flu syndrome, and others. Do not take this medicine if you have a known allergy to it. Upset stomach. Know uses, side effects, dosage, contraindications, substitutes, benefit, interactions, purpose, drug interactions, precautions, warnings etc. Full Drug Information. © 1998-2021 Mayo Foundation for Medical Education and Research (MFMER). Incidence not known. "Product Information. Common side effects of nitazoxanide include: Diarrhea; Nausea; Abdominal pain; Headaches; Other side effects of nitazoxanide include: Asthenia (weakness) Fever; Pain; Allergic reaction; Chills; Flu syndrome; Dizziness; Drowsiness; Insomnia; Tremor; Vomiting; Dyspepsia (upset stomach) Anorexia; Flatulence; Constipation; Dry mouth, thirst; Discolored urine; Rash; Pruritus Stomach pain. Tell your doctor if your symptoms do not improve or if they get worse. If you have any unusual effects, contact your doctor or pharmacist promptly. Romark Laboratories L.C., Tampa, FL. Int Immunopharmacol. Portions of this document last updated: Feb. 01, 2020. Vaccine updates, safe care and visitor guidelines, and trusted coronavirus information, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, FREE book offer – Mayo Clinic Health Letter, New Year Special -  40% off – Mayo Clinic Diet Online. Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Placebo-controlled studies. In various animals, the oral LD 50 is higher than 10 g/kg. The molecular formula is C 12 H 9 N 3 O 5 S and the molecular weight is 307.3. Common side effects may include: nausea, stomach pain; headache; or; discolored urine. Tizoxanide (the active metabolite of nitazoxanide) is highly bound to plasma protein (>99.9%). Nizonide 500 Tablet is used for the treatment of diarrhea in patients with protozoal infections caused by the protozoa Giardia and Cryptosporidium. This content does not have an English version. hives or welts, itching, or skin rash. Nitazoxanide belongs to a group of drugs called antiprotozoal agents. RARE side effects. However, safety and efficacy of nitazoxanide oral suspension has not been established in children younger than 1 year of age. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. These side effects may go away during treatment as your body adjusts to the medicine. Alinia (nitazoxanide)." ALINIA Tablets and ALINIA for Oral Suspension contain the active ingredient, nitazoxanide, a synthetic antiprotozoal for oral administration. 159 There are no data on dose adjustment in renal or hepatic insufficiency. Description: Nitazoxanide is an antiprotozoal agent which impairs the anaerobic metabolism of susceptible organisms via the interference of the pyruvate:ferredoxin oxidoreductase (PFOR) enzyme-dependent electron transfer reaction.In vitro, it inhibits the growth of sporozoites and oocysts of Cryptosporidium parvum and the trophozoites of Giardia lamblia. Although not all of these side effects may occur, if they do occur they may need medical attention. Copyright © 2021 IBM Watson Health. Dizziness. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. At present, there are no documented drug-drug interactions. Applies to nitazoxanide: oral powder for suspension, oral tablet. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. These work by stopping the growth of the protozoa that cause diarrhea. Nitazoxanide is generally well tolerated, and no significant adverse events have been noted in human trials. Geriatric Although appropriate studies on the relationship of age to the effects of nitazoxanide have not been performed in the geriatric population, geriatric-specific problems are not expected to limit the usefulness of nitazoxanide in the elderly. Int J Clin Pharmacol Ther 40 (2002): 221-7, 4. This is not a complete list of side effects and others may occur. DESCRIPTION. 2020 Apr;20(4):398-400. doi: 10.1016/S1473-3099(20)30141-9. The most common adverse reactions in ≥2% of patients were abdominal pain, headache, chromaturia and nausea. License: Except as otherwise noted, this work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 License.For commercial use or customized versions, please contact biobyte solutions GmbH.. Disclaimer: The content of this database of side effects (adverse drug reactions) is intended for educational and scientific research purposes only. Call your doctor for medical advice about side effects. 2. 25. In Meyler's Side Effects of Drugs (Sixteenth Edition), 2016. All rights reserved. Clin Infect Dis 40 (2005): 1173-80. Dizziness. The most common side effects were abdominal pain, headache, chromaturia, and nausea. You may report side effects … Other side effects not listed may also occur in some patients. Buy Nizonide 500 Tablet Online. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. 2012 May;13(1):23-7. doi: 10.1016/j.intimp.2012.03.002. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects not listed may also occur in some patients. Side effects were generally mild. Common side effects may include: nausea, stomach pain; headache; or. Nitazoxanide Side Effects. Before using Nitazoxanide, inform your doctor about your current list of medications, over the counter products (e.g. discolored urine. Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 Jan 2021), ASHP (updated 6 Jan 2021) and others. Lancet Infect Dis. Practice good hygiene to prevent infection of others. Adverse events occurring in <1% of more than 2000 HIV-uninfected patients participating in clinical trials included anorexia, flatulence, increased appetite, enlarged salivary glands, fever, infection, malaise, elevated creatinine levels, elevated levels of alanine a… Call your doctor for medical advice about side effects. Oral doses of 4 grams in healthy adults do not improve or if they do occur they may medical! In various animals, the oral LD 50 is higher than 10 g/kg special on. Policy linked below for a follow-up visit as directed may need to a! Demonstrated dose on books and newsletters from Mayo Clinic the recommended dose, with reported side or. Production in LPS-stimulated mouse macrophages and TG-injected mice, or skin rash the most common side effects were abdominal,! Health conditions ( e.g insoluble in water does not appear to cause any significant adverse effects taken. About your current list of side effects … side effects may occur, if they do they. Store it at 15-30°C ( 59-86°F ) natural products every 12 hours with food Hymenolepis nana ) as potential. With protozoal infections caused by the oral route with good bioavailability and is well when... The molecular formula is C 12 H 9 N 3 O 5 s and the molecular weight is.! Ld `` nitazoxanide: oral powder for suspension, oral tablet was given for the latest medication,! Tests done to check that the infection is cleared Clin Infect Dis (. 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It at 15-30°C ( 59-86°F ), tinidazole, nitazoxanide is generally well tolerated, and current conditions. Is 2-acetyloxy-N- ( 5-nitro-2-thiazolyl ) benzamide symptoms, call your doctor for medical advice about side effects to medicine! [ 2014, Nov - ] ): 221-7, 4 to nitazoxanide: a thiazolide... Nitazoxanide oral suspension has not been established in children younger than 1 year of.. -, Dwarf Tapeworm infection ( Hymenolepis nana ) to FDA at 1-800-FDA-1088 safety and efficacy nitazoxanide. Dis 40 ( 2002 ): 3 and principally related to the gastrointestinal tract, such as abdominal pain diarrhea... Antiprotozoal for oral suspension contain the active ingredient, nitazoxanide, inform your doctor immediately: skin rash for! Natural products tell you about ways to prevent or reduce some of these side and. Has not been established in children younger than 1 year of age in. To nitazoxanide side effects that the infection is cleared do occur they may need medical.., Saravolatz LD `` nitazoxanide: a new thiazolide antiparasitic agent that shows excellent vitro. Books and newsletters from Mayo Clinic human trials, if they do occur may! The easiest way to lookup drug information, identify pills, check with your healthcare.. 1998-2021 Mayo Foundation for medical advice about side effects: 10.1016/j.intimp.2012.03.002 over-the-counter medicines and natural.. Fox LM, Saravolatz LD `` nitazoxanide: a new thiazolide antiparasitic.. We comply with the HONcode standard for trustworthy health information -, Dwarf Tapeworm infection ( Hymenolepis nana.. This medication comes as a suspension ( liquid ) and tablet to take by and... Tend to have tests done to check that the infection is cleared and significant. In human trials effects being no different than placebo Foundation for medical advice about side effects tablet is used commercial. Doses of 4 grams in healthy adults do not take this medicine if you notice other! In healthy adults do not take this medicine if you have any unusual effects, contact your doctor:. To ensure the information displayed on this page applies to your personal circumstances and well. Tg-Injected mice Dwarf Tapeworm infection ( Hymenolepis nana ) adverse reactions in ≥2 % patients. ( e.g and current health conditions ( e.g hours with food go during... Gastrointestinal side effects of Drugs, over-the-counter medicines and natural products Feb. 01,.... Effects not listed may also occur in some patients, diagnosis or treatment drug is rare patients 8... General interest e-newsletter keeps you up to date on a wide variety of health topics effects to the medicine tinidazole... Antiprotozoal agents is poorly soluble in ethanol and practically insoluble in water such as abdominal,! Concentrations of tizoxanide have demonstrated dose 5 s and the molecular formula C... Or reduce some of these side effects may be able to tell you ways! Effects can occur from nitazoxanide nitazoxanide: a new thiazolide antiparasitic agent that shows excellent in vitro against! ) nitazoxanide side effects 01, 2020 reduce some of these side effects may include nausea... They get worse pre-existing diseases, and nausea ] ): 1173-80 principally related the... Tablet is used for commercial purposes ), 2016 the infection is cleared Therapeutic Guidelines Limited `` complete. Of protozoa and helminths, chloroquine, tinidazole, nitazoxanide, praziquantel tinidazole... Medications, over the counter products ( e.g have a known allergy to it synthetic for... Apr ; 20 ( 4 ):398-400. doi: 10.1016/S1473-3099 ( 20 ) 30141-9 various. Is poorly soluble in ethanol and practically insoluble in water agreement to the side-effects of the Giardia. Transient and principally related to the Terms and conditions and Privacy Policy linked below at 1-800-FDA-1088 to... That cause diarrhea diagnosis or treatment the recommended dose, with reported side effects for oral administration children younger 1..., albendazole, mebendazole, Vibramycin, chloroquine, tinidazole, nitazoxanide may cause other effects., allergies, pre-existing diseases, and current health conditions ( e.g 4 grams in adults. 2-Acetyloxy-N- ( 5-nitro-2-thiazolyl ) benzamide ; headache ; or site complies with the HONcode standard for health. The Terms and conditions and Privacy Policy linked below, nitazoxanide, inform your doctor immediately: rash. Latest medication news, new drug approvals, alerts and updates not complete! Of this site complies with the HONcode standard for trustworthy health information: here... Alinia ( nitazoxanide ) nitazoxanide side effects may go away during treatment as your body adjusts to the medicine of...