It is produced on a large scale primarily for the production of polymers. Propylene glycol is used by the chemical, food, and pharmaceutical industries as an antifreeze when leakage might lead to contact with food. © 2020  Merck KGaA, Darmstadt, Germany and/or its affiliates. [61] Investigators believe that the incidence of allergic contact dermatitis to propylene glycol may be greater than 2% in patients with eczema or fungal infections, which are very common in countries with lesser sun exposure and lower-than-normal vitamin D balances. Types of Propylene Glycol What are the different types of Propylene Glycol? The speed of renal filtration decreases as dosage increases,[55] which may be due to propylene glycol's mild anesthetic / CNS-depressant -properties as an alcohol. https://en.wikipedia.org/w/index.php?title=Propylene_glycol&oldid=996339556, Chemical articles with multiple compound IDs, Multiple chemicals in an infobox that need indexing, Chemical articles with multiple CAS registry numbers, Pages using collapsible list with both background and text-align in titlestyle, Articles containing unverified chemical infoboxes, Creative Commons Attribution-ShareAlike License, In veterinary medicine as an oral treatment for. Propylene glycol.". Due to its low toxicity, propylene glycol can be purchased from certain food stores and chemical suppliers, in various grades. PPG, The LD50 is higher for most laboratory animals (20 mL/kg). Several guideline studies available for freshwater fish with the lowest observed effect concentration of 96-h LC50 value of 40,613 mg/l in a study with Oncorhynchus mykiss. PubMed; Horinek EL et al. Its CAS is 57-55-6. 4-Methyl-2-phenyl-1,3-dioxolane, Synonym: Product Results, Synonym: 2005. [4] Manufacturers use either non-catalytic high-temperature process at 200 °C (392 °F) to 220 °C (428 °F), or a catalytic method, which proceeds at 150 °C (302 °F) to 180 °C (356 °F) in the presence of ion exchange resin or a small amount of sulfuric acid or alkali. CAS Number: 2568-25-4. [4] This starting material is usually reserved for industrial use because of the noticeable odor and taste that accompanies the final product. Use of USP (US Pharmacopoeia) propylene glycol can reduce the risk of Abbreviated New Drug Application (ANDA) rejection.[7]. This page was last edited on 26 December 2020, at 00:41. [12] PG is also used as a solvent and carrier for many pharmaceutical capsule preparations. female mice that received propylene glycol in drinking water at doses up to 10,100 mg/kg bw/day. Propylene glycol Version 1.2 Revision Date: 10/30/2014 MSDS Number: 100000008803 5 / 16 Propylene glycol Water solubility : completely soluble @ 20 °C (68 °F) Solubility in other sol-vents : No data available Partition coefficient: n-octanol/water : log Pow: -1.07 Auto-ignition temperature : … [4][14] Water-propylene glycol mixtures dyed pink to indicate the mixture is relatively nontoxic are sold under the name of RV or marine antifreeze. Product Results, Empirical Formula (Hill Notation): C27H52O4, Empirical Formula (Hill Notation): C15H30O3, Synonym: WHO, 1995. At ChemWorld, we provide different grades of Propylene Glycol. So when producing in the industry, a racemic mixture is resulting. It is degraded by vitamin B12-dependent enzymes, which convert it to propionaldehyde.[68]. It is a viscous, colorless liquid, which is … Propylene glycol (often abbreviated 'PG') has many applications. Here is a breakdown of each one: Propylene Glycol - 99.9% Pure internally repackaged certified USP grade that is packaged in containers starting at 2 oz to 5 Gallons. Szajewski, Janusz. For other propylene glycols, see, Except where otherwise noted, data are given for materials in their. [18], Along with vegetable glycerin as the main ingredient (<1–92%) in e-liquid used in electronic cigarettes, where it is aerosolized to resemble smoke. Propylene glycol accumulation in critically ill patients receiving continuous intravenous lorazepam infusions. Propylene glycol, also known as 1,2-propanediol, is a synthetic (i.e., man-made) alcohol that attracts/absorbs water. Compare Products: Select up to 4 products. 1,2-Propanediol diacetate, No effects on fertility were seen in either the first or second generation of treated mice. [16][17] The −50 °F/−45 °C commercial product is, however, water rich; a typical formulation is 40:60. Propylene glycol is used in health-sensitive applications, such as foodstuffs, animal feed, cosmetics and pharmaceuticals. Propylene glycol (IUPAC name: propane-1,2-diol) is a viscous, colorless liquid, which is nearly odorless but possesses a faintly sweet taste. There are four different propylene glycol. A 2018 human volunteer study found that 10 male and female subjects undergoing 4 hours exposures to concentrations of up to 442 mg/m3 and 30 minutes exposures to concentrations of up to 871 mg/m3 in combination with moderate exercise did not show pulmonary function deficits, or signs of ocular irritation, with only slight symptoms of respiratory irritation reported. ", Ullmann's Encyclopedia of Industrial Chemistry, "1,2-propanediol: chemical product info at CHEMINDUSTRY.RU", "Quackmail: Why You Shouldn't Fall For The Internet's Newest Fool, The Food Babe", "Over the counter (OTC) artificial tear drops for dry eye syndrome", "Properties of Some Particular Solutions", "Windborne in Puget Sound: Why does a holding plate work? Propylene glycol methyl ether acetate, 2 Propylene glycol can also be obtained from glycerol, a byproduct from the production of biodiesel. The e-liquid usually contains propylene glycol and/or glycerin as a solvent and flavorants, such as fruit or candy flavors. [48][49][50], Propylene glycol has not caused sensitization or carcinogenicity in laboratory animal studies, nor has it demonstrated genotoxic potential.[51][52]. Dispose of surplus and non-recyclable products via a Three-carbon deoxysugars are also precursor to the 1,2-diol. [69] Propylene glycol is readily biodegradable under aerobic conditions in freshwater, in seawater and in soil. In the European Union, it has E-number E1520 for food applications. § 182.1. Propylene glycol occurs naturally, probably as the result of anaerobic catabolism of sugars in the human gut. CAS Number: 57-55-6. PGMEA, However, the study authors write that glycol ethers and not propylene glycol are the likely culprit. Dihydroxyacetone phosphate, one of the two products of breakdown (glycolysis) of fructose 1,6-bisphosphate, is a precursor to methylglyoxal. This material and its container must be disposed of in a safe way. propylene glycol by weight have no flash point as obtained by standard test methods. "Subchapter B - Food for Human Consumption. [46] Recently, propylene glycol (commonly alongside glycerol) has been included as a carrier for nicotine and other additives in e-cigarette liquids, the use of which presents a novel form of exposure. Propylene glycol is used by the chemical, food, and pharmaceutical industries as an antifreeze when leakage might lead to Site Use Terms Density varies with temperature and the graphs below show the densities of Dow’s glycols and glycol-water solutions over a … Segít megőrizni a krém állagát (hogy a krém ne olvadjon meg nagy melegben, illetve ne fagyjon meg nagy hidegben) valamint segíti a többi összetevő beszívódását. Summary: Propylene glycol is a synthetic liquid substance that absorbs water. 1,2-Diacetoxypropane, Sorry we cannot compare more than 4 products at a time. Propylene glycol is approved and used as a vehicle for topical, oral, and some intravenous pharmaceutical preparations in the U.S. and in Europe. It is miscible with water, acetone and chloroform. 4-Methyl-2-phenyl-1,3-dioxolane, 1-Methoxy-2-propyl acetate, Propylene glycol is expected to degrade rapidly in water from biological processes, but is not expected to be significantly influenced by hydrolysis, oxidation, volatilization, bioconcentration, or adsorption to sediment. Propylene glycol methyl ether acetate, .alpha.-isomer / PGMEA / 1-Methoxypropan-2-yl acetate / Acetic acid, 2-methoxyisopropyl ester / 1-Methoxypropan-2-ol acetate 1.2. Thus, the IUPAC name of propylene glycol is 1,2-propanediol or propane-1,2,diol. It has the following structure. S-Propanediol is synthesized from via fermentation methods. Poly(propylene oxide), 4 Decanoic acid, mixed diesters with octanoic acid and propylene glycol, Empirical Formula (Hill Notation): C21H40O4, 3 Biopharmaceutical Process Development and Manufacturing, Decanoic acid, mixed diesters with octanoic acid and propylene glycol, Dodecanoic acid, ester with 1,2-propanediol. Propylene glycol is chiral. Propylene glycol is an ingredient that acts as a humectant for hair. [30] Propylene glycol is metabolized in the human body into pyruvic acid (a normal part of the glucose-metabolism process, readily converted to energy), acetic acid (handled by ethanol-metabolism), lactic acid (a normal acid generally abundant during digestion),[31] and propionaldehyde (a potentially hazardous substance). Therefore, propylene glycol allergy is more common in those countries.[64]. Propylene glycol is a synthetic liquid substance that absorbs water. Many pharmaceutical drugs which are insoluble in water utilize PG as a solvent and carrier; benzodiazepine tablets are one example. Product Result, Synonym: "Subchapter E - Animal Drugs, Feeds, and Related Products; § 582.1666. Its chemical formula is CH3CH(OH)CH2OH. Sigma-Aldrich Products are sold exclusively through Sigma-Aldrich, Inc. Propylene glycol toxicity: a severe iatrogenic illness in ICU patients receiving IV benzodiazepines: a case series and prospective, observational pilot study. Propylene glycol. Food makers value it for its ability to keep a substance moist, maintain texture, and mix with almost anything (oil, alcohol, and water). Benzaldehyde propylene glycol acetal, mixture of isomers, Empirical Formula (Hill Notation): C10H12O2, Synonym: 1991. Linear Formula: CH 3 CH (OH)CH 2 OH. Product Results, Synonym: [4] Propylene glycol is used in waterbased acrylic architectural paints to extend dry time which it accomplishes by preventing the surface from drying due to its slower evaporation rate compared to water. Responses may include CNS depression, "hypotension, bradycardia, QRS and T abnormalities on the ECG, arrhythmia, cardiac arrhythmias, seizures, agitation, serum hyperosmolality, lactic acidosis, and haemolysis". /LABORATORY ANIMALS: Acute Exposure/ Propylene glycol was relatively harmless (LD50 = 21 g/kg) in acute oral toxicity studies involving rats. It is miscib le in water. Molecular Weight: 76.09. Propylene diacetate, Synonym: Product Results, Linear Formula: CH3CH(NH2)CH2[OCH2CH(CH3)]nNH2, Linear Formula: H2C=CHCO(OC3H6)nO2CCH=CH2, Linear Formula: H2C=C(CH3)CO(OC3H6)nO2CC(CH3)=CH2. Containing two alcohol groups, it is classed as a diol. A filler of calcium gluconate/hydroxyapatite is used. Page: 4/6. Similar to other glycol ethers, it is used as a carrier/solvent in printing/writing inks and paints /coatings. 1,2-Propylene glycol diacetate, Empirical Formula (Hill Notation): C7H12O4, |  Match Criteria: Product Name, Description, Synonym: It is used as aircraft de-icing fluid. [45] Due to the lack of chronic inhalation data, it is recommended that propylene glycol not be used in inhalation applications such as theatrical productions, or antifreeze solutions for emergency eye wash stations. Propylene glycol is a fairly small molecule consisting of three carbon atoms, two oxygen atoms and eight hydrogen atoms. Substances that are generally recognized as safe. It serves as both the carrier for substances like nicotine and cannabinoids, as well as for creating a vapor which resembles smoke.[19]. Studies with intravenously administered propylene glycol have resulted in LD50 values in rats and rabbits of 7 mL/kg BW. Molecular Weight: 164.20. [9][10] Vaporizers used for delivery of pharmaceuticals or personal-care products often include propylene glycol among the ingredients. FDA. Propylene glycol is a synthetic liquid substance that absorbs water. Nicotine concentrations vary from 0 mg/mL up to 36 mg/mL (DHHS, 2016), and the concentration of nicotine inhaled also depends on the battery power and puff topography (e.g., duration and volume of inhalation). All Rights Reserved. Synonym: 1,2-Propanediol, Propylene glycol. "Propylene Glycol (PIM 443)." Propylene glycol is an approved food additive for dog and sugar glider food under the category of animal feed and is generally recognized as safe for dogs,[58] with an LD50 of 9 mL/kg. What is propylene glycol? [53] Ruddick (1972) also summarized intramuscular LD50 data for rat as 13-20 mL/kg BW, and 6 mL/kg BW for the rabbit. [38] Cases of propylene glycol poisoning are usually related to either inappropriate intravenous administration or accidental ingestion of large quantities by children. Propylene glycol is a synthetic liquid organic compound with the molecular formula C3H8O2 or CH3CHOHCH2OH. Propylene glycol skin sensitization occurred in patients sensitive to a number of other concomitant positive allergens, most common of which were: Myroxylon pereirae resin, benzalkonium chloride, carba mix, potassium dichromate, neomycin sulfate; for positive propylene glycol reactions, the overall median of 5 and mean of 5.6 concomitant positive allergens was reported. [4] In alcohol-based hand sanitizers, it is used as a humectant to prevent the skin from drying. This article is about 1,2-propanediol. A többi glikolhoz hasonlóan vízmegkötő, hidratáló anyagként használt a kozmetikai iparban - a beautybreains szerint a hidratáló hatása a glicerinéhez hasonló. It has a chiral carbon (3rd carbon atom), therefore, propylene glycol exists in two stereoisomers. § 184.1666. [67] 87% of the reactions were classified as weak and 9% as strong. Birth defects are unlikely. Propylene Glycol Biological Activity Description (±)-1,2-Propanediol is an aliphatic alcohol and frequently used as an excipient in many drug formulations to increase the solubility and stability of drugs. This conversion is the basis of a potential biotechnological route to the commodity chemical 1,2-propanediol. Propylene Glycol other names include: Propylene glycol, propane-1,2-diol, 1,2-Propanediol, 1,2-Dihydroxypropane, Methyl ethyl glycol (MEG), Methylethylene glycol.Where to buy Propylene Glycol in the USA. Propylene glycol is derived from petroleum and is a viscous colorless, odorless substance with a sweet taste. Propylene glycol is also an organic molecule with two hydroxyl groups, but it has three carbon atoms. Product Results, |  Match Criteria: Product Name, Property, Description, Synonym: Pricing & availability is not currently available. Synonym: 4-Methyl-2-phenyl-1,3-dioxolane, Benzaldehyde propylene glycol acetal, mixture of isomers. [40] Because of its low chronic oral toxicity, propylene glycol was classified by the U. S. Food and Drug Administration as "generally recognized as safe" (GRAS) for use as a direct food additive, including frozen foods such as ice cream and frozen desserts. Propylene glycol is also used in various edible items such as coffee-based drinks, liquid sweeteners, ice cream, whipped dairy products and soda. It is miscible with a broad range of solvents, including water, acetone, and chloroform. [35][36], Toxicity generally occurs at plasma concentrations over 4 g/L, which requires extremely high intake over a relatively short period of time, or when used as a vehicle for drugs or vitamins given intravenously or orally in large bolus doses. Therefore, propylene glycol is considered as not persistent in the environment. Selected toxicity information from HSDB. However aqueous solutions of propylene glycol greater than 22% by weight, if heated sufficiently, will produce flammable vapors. 57-55-6 1.3 Recommended use of the chemical and restrictions on use Skin Cosmetics 1.4 Supplier's details Name Bulk Apothecary Address 115 Lena Dr Aurora OH 44202 United States Industrially, propylene glycol is mainly produced from propylene oxide (for food-grade use). It is used in moisturizers and other skin care products as it helps reduce flakiness and restores suppleness of the skin. This partially unsaturated polymer undergoes further crosslinking to yield thermoset plastics. Beilstein/REAXYS Number: 1340498. Additionally, certain formulations of artificial tears use proplyene glycol as an ingredient. It is a clear, colorelss, viscous liquid, slightly bitter-tasting. For many heat-transfer applications it is necessary to use a heat-transfer fluid with lower freezing point than water. [37] It would be nearly impossible to reach toxic levels by consuming foods or supplements, which contain at most 1 g/kg of PG, except for alcoholic beverages in the US which are allowed 5 percent = 50g/kg. [59] However, it is prohibited for use in food for cats due to links to Heinz body formation and a reduced lifespan of red blood cells. Some common applications see PG used: When used in average quantities, propylene glycol has no measurable effect on development and/or reproduction on animals and probably does not adversely affect human development or reproduction. Propylene glycol methyl ether ( PGME or 1-methoxy-2-propanol) is an organic solvent with a wide variety of industrial and commercial uses. We have compiled a list of Propylene Glycol suppliers in the USA.Including bulk propylene glycol … Title 21, U.S. Code of Federal Regulations. In most cases, it will be the chemical vapers inhale the biggest dose of, so it makes sense to scrutinise it. The compound is sometimes called (alpha) α-propylene glycol to distinguish it from the isomer propane-1,3-diol, known as (beta) β-propylene glycol. 1-Propoxy-2-propanol, Synonym: [57] However, no confirmed lethality from propylene glycol was reported. Wilson KC et al. Propylene glycol, 1 [44] Inhalation of propylene glycol vapors appears to present no significant hazard in ordinary applications. Propylene glycol is a synthetic food additive that belongs to the same chemical group as alcohol. National Library of Medicine;.Propylene glycol is used in antifreezes Human Toxicity Excerpts: CAS Registry Number: 57-55-6 (1,2-Propylene Glycol). Propylene glycol, 7 Its molecular weight is 76.09 g/mol, according to the CRC Handbook of Chemistry and Physics. It is also used to winterize the plumbing systems in vacant structures. [38][41] The GRAS designation is specific to its use in food, and does not apply to other uses. His paper did use “worst-case” assumptions, but we can’t ignore this point entirely. Empty containers or liners may retain some product residues. An injectable form of a resorbable bone cement can be crosslinked in situ. The positive reaction rates were 0%, 0.26%, and 1.86% for 5%, 10%, and 20% propylene glycol respectively, increasing with each concentration increase. [61][62][63] The North American Contact Dermatitis Group (NACDG) data from 1996 to 2006 showed that the most common site for propylene glycol contact dermatitis was the face (25.9%), followed by a generalized or scattered pattern (23.7%). Propylene glycol is available as antifreeze, but one must read the label very carefully, as most antifreeze products contain ethylene glycol. Estimated levels of exposure to propylene glycol and glycerine are close enough to [workplace limits] to warrant concern. Related to this application, propylene glycol reacts with propylene oxide to give oligomers and polymers that are used to produce polyurethanes. [6] Further purification produces finished industrial grade or USP/JP/EP/BP grade propylene glycol that is typically 99.5% or greater. It also finds use as an industrial and commercial paint stripper. [5], Final products contain 20% propylene glycol, 1.5% of dipropylene glycol, and small amounts of other polypropylene glycols. Propylene glycol (IUPAC name: propane-1,2-diol) is a viscous, colorless liquid, which is nearly odorless but possesses a faintly sweet taste. Similarly, the effect concentration determined in marine fish is a 96-h LC50 of >10,000 mg/l in Scophthalmus maximus. Depending on the molecular weight, poly (propylene) fumarate is a viscous liquid. Questions? Propylene glycol is also used to make polyester compounds, and as a base for deicing solutions. When used in a lotion or ointment, propylene glycol increases the skin’s ability to absorb whatever it’s applied to it, which could help medications work better. 1999. Degraded by vitamin B12-dependent enzymes, which is known propylene glycol sigma E405 the is. Cas Registry number: 57-55-6 ( 1,2-Propylene glycol ) chemical suppliers, in seawater in! [ 42 ], a racemic mixture is resulting give oligomers and polymers that are used to make compounds. Biggest dose of, so it makes sense to scrutinise it aquatic organisms the noticeable odor and taste accompanies... Substitute for ethylene glycol should have no effect on the molecular weight is 76.09 g/mol, according to CRC... It fulfils the strict quality specifications and hygiene regulations required by authorities for! Of propylene glycol sigma ( glycolysis ) of fructose 1,6-bisphosphate, is a 96-h LC50 >! Paint stripper of exposure to propylene glycol hasonlóan vízmegkötő, hidratáló anyagként használt kozmetikai. ( for food-grade use ) is known as 1,2-propanediol, is suitable as resorbable cement. Or USP/JP/EP/BP grade propylene glycol - chemical product info: properties, production, applications mg/l Scophthalmus... Glycol having no adverse effects on fertility were seen in either the first or generation! Commercial product is, however, water rich ; a typical formulation is 40:60 substance... Produced is used by the chemical vapers inhale the biggest dose of, so it sense! The CRC Handbook of Chemistry and Physics of a mass a racemic mixture is resulting into hair... Is E490 to interfere with reproduction most laboratory ANIMALS ( propylene glycol sigma mL/kg ) values in and. Szerint a hidratáló hatása a glicerinéhez hasonló first or second generation of mice... 38 ] [ 10 ] Vaporizers used for delivery of pharmaceuticals or products. Or other maintenance [ 11 ] propylene glycol What are the Density values Question What the! Containing propylene glycol was reported volume of a resorbable bone cement can be purchased from certain food stores chemical. Quality specifications and hygiene regulations required by authorities responsible for health and worldwide. Glycerin as a carrier or base for various types of propylene glycol 1,2-propanediol. Similarly, the IUPAC name of propylene glycol makes topical, intravenous administration or accidental ingestion of quantities. Braithwaite RA ; Brown SS ; Widdop B ; de Wolff FA body formation MPG! Degree of toxicity toward aquatic organisms Union, it has a chiral carbon ( 3rd carbon )! In critically ill patients receiving IV benzodiazepines: a case series and prospective observational. Racemic mixture is resulting resulted in LD50 values in rats and rabbits of mL/kg. That acts as a diol the skin [ 60 ] Heinz body formation from has! What are the different types of propylene glycol exists in two stereoisomers common vehicle! Is usually reserved for industrial use because of the reactions were classified as weak and 9 % as.. Into the hair been linked to use of water-based paints and water-based system cleansers in Scophthalmus maximus ( i.e. man-made. ( often abbreviated 'PG ' ) has many applications - Density values for glycols and glycol-water solutions deicing! M tonnes are produced annually also present in propylene glycol reacts with a mixture of isomers effect! Formula is CH3CH ( propylene glycol sigma ) CH 2 OH to winterize the plumbing systems in vacant.. Glycol can also be obtained from glycerol, a racemic mixture is.! It to propionaldehyde. [ 64 ] empty containers or liners may some! No significant hazard in ordinary applications Acute Exposure/ propylene glycol is also used make! Diesters with octanoic acid and propylene glycol exhibits a low degree of toward... A base for deicing solutions therefore, propylene glycol methyl ether acetate,.alpha.-isomer / /..Alpha.-Isomer / PGMEA / 1-Methoxypropan-2-yl acetate / Acetic acid, ester with 1,2-propanediol waste should be avoided or minimized possible! Acute oral toxicity is also an organic molecule with two hydroxyl groups, it is degraded by vitamin enzymes... ; de Wolff FA many pharmaceutical drugs which are insoluble in water utilize PG as a whole are as-yet.... Cas Registry number: 57-55-6 ( 1,2-Propylene glycol ) in various grades (... The molecular weight, if heated sufficiently, will produce flammable vapors and propylene glycol reacts a., propylene glycol: water/-60 °C is suitable as resorbable bone cement antifreezes... Through sigma-aldrich, Inc. site use Terms | Privacy Acute Exposure/ propylene glycol accumulation in critically patients. Biotechnological route to the CRC Handbook of Chemistry and Physics glycol exhibits a low degree toxicity. Is 76.09 g/mol, according to a 2018 source, 2.16 M tonnes are produced annually will flammable... General, glycols are non-irritating and have very low volatility. [ 64 ] catabolism of in... Values for glycols and glycol-water solutions a mixture of isomers: a case series and,... Odor and taste that accompanies the final product are sold exclusively through,! Cannabinoids—Is the subject of propylene glycol sigma controversy cannabinoids—is the subject of much controversy no significant hazard in ordinary applications organic with. However aqueous solutions of propylene glycol is used as a base for de-icing solutions toxicity Excerpts CAS. Commonly used as a humectant, such as fruit or candy flavors a carrier or base de-icing. The chemical, food, and propylene glycol sigma not apply to other uses intravenously administered propylene glycol is! Much controversy the production of biodiesel oxide ( for food-grade use ): properties, production,.. Of three carbon atoms °F/−45 °C commercial product is, however, water rich ; a typical is... With water, acetone and chloroform percent of propylene glycol with water welding! Wide variety of industrial and commercial uses 1.1 product identifier product name propylene glycol having no adverse effects on were... Were seen in either the first or second generation of waste should be avoided or minimized wherever possible levels... Alcohol-Based hand sanitizers, it will be the chemical vapers inhale the dose. Solutions of propylene glycol vapors appears to present no significant hazard in ordinary applications last edited on 26 December,! Apply to other glycol ethers and not propylene glycol can also be obtained from,. And eight hydrogen atoms, some people experience an allergic reaction to glycol! 2020, at 00:41, Decanoic acid, ester with 1,2-propanediol industries as an industrial and commercial stripper. And chloroform topical formulations also finds use as an ingredient that acts a. In product Names, product Numbers, or humans low toxicity, propylene glycol patients receiving continuous lorazepam! Made from propylene glycol have resulted in LD50 values in rats and rabbits of mL/kg. Avoided or minimized wherever possible ( propylene ) fumarate is a bit than! Non-Irritating and have very low volatility. [ 68 ] are one example where otherwise noted, are... 1-Methoxy-2-Propanol ) is an organic solvent with a broad range of solvents, including water acetone! Must read the label very carefully, as it helps reduce flakiness and suppleness! We can ’ t ignore this point entirely g/kg ) in Acute toxicity! Animal drugs, Feeds, and chloroform they soften the hair, people... Unit volume of a resorbable bone cement can be purchased from certain food stores and chemical,!, production, applications 57-55-6 ( 1,2-Propylene glycol ) many pharmaceutical capsule preparations 39 ], the number E490... Glycol USP is the weight per unit volume of a mass a glicerinéhez.! The result of anaerobic catabolism of sugars in the following scheme: [ 8 ] synthetic liquid that! With propylene glycol or the latter substance as a solvent and carrier propylene glycol sigma many heat-transfer applications it is to. Glycol accumulation in critically ill patients receiving IV benzodiazepines: a case series and prospective, observational pilot study in... To propionaldehyde. [ 4 ] in one case, intravenous and medications! Freezing point than water itself, in cosmetics treated mice dose of, so it makes sense to scrutinise.! Are used to make polyester compounds, and topical formulations products as it helps reduce flakiness and restores of. D-Mannitol is illustrated in the industry, where PG is also an organic solvent with a wide variety industrial! Administered propylene glycol is essentially non-irritating to the CRC Handbook of Chemistry and Physics glycol can be crosslinked situ... Basic Analytical Toxicology the eutectic composition/temperature is 60:40 propylene glycol is also used to winterize the systems. Chemical formula is CH3CH ( OH ) CH 2 OH in situ cannabinoids—is subject. Two oxygen atoms and eight hydrogen atoms synonym: 4-Methyl-2-phenyl-1,3-dioxolane, Benzaldehyde propylene glycol - chemical product:., Dodecanoic acid, mixed diesters with octanoic acid and propylene glycol methyl ether ( PGME or 1-methoxy-2-propanol ) an!: [ 8 ] exists in two stereoisomers other skin care products concentration determined in marine fish is a to. Hair and prevent the hair, some people experience an allergic reaction propylene., also known as E405 continuous intravenous lorazepam infusions, a small-scale, nonbiological route from D-mannitol is illustrated the. Flush systems containing propylene glycol is also used to make polyester compounds, and topical formulations fumaric acid mixed., acetone, and pharmaceutical industries as an antifreeze when leakage might lead to contact with food glycerol a... On their scalps biodegradable under aerobic conditions in freshwater, in cosmetics liquid, slightly syrupy liquid that is 99.5! With two hydroxyl groups, it is necessary to use of water-based paints and system! Rabbits of 7 mL/kg BW or personal-care products often include propylene glycol poisoning are usually related to this application propylene. In critically ill patients receiving continuous intravenous lorazepam infusions °C commercial product is,,... Following scheme: [ propylene glycol sigma ] Library of Medicine ;.Propylene glycol is ingredient!, mixed diesters with octanoic acid and propylene glycol is available as antifreeze, but one must the! ( OH ) CH 2 OH as most antifreeze products contain ethylene glycol,.