Extensive mortality occurred in rats that received prolonged exposure to 100 ppm styrene oxide while 300 ppm was rapidly lethal. • Category 1B for reproductive toxicity “a presumed human reproductive toxicant” – The SPA undertook a careful assessment of the available scientific data and concluded that the weight of available evidence demonstrates that Styrene is not selectively toxic to development and hence classification for reproductive toxicity is not warranted. General information; Classification & Labelling & PBT assessment; Manufacture, use & exposure noviembre 19, 2020; schließen Weitere Informationen über unsere Verwendung von Cookies. The listing of α-methyl styrene for the endpoint of female reproductive toxicity is effective July 29, 2011. Nonneoplastic lesions were observed in the brain, thymus, spleen, liver, kidney, and reproductive organs of males and females and were considered due to overt toxicity. Styrene will polymerise when contaminated by oxidising agents and most halides. Regulatory Toxicology and Pharmacology ISSN: 0273-2300 EISSN: 1096-0295 Volume. A review of the developmental and reproductive toxicity of styrene Author(s) Brown, NA; Lamb, JC; Brown, SM; Neal, BH Year. He has published over 25 such articles in peer-reviewed journals, including the review article “Styrene Metabolism and Toxicokinetics in the SIRC Review” (1994), and, more recently, “Two Generation Reproduction Study of Styrene by Inhalation in Crl-CD Rats”. 2000 Is Peer Reviewed? Article. The reproductive and developmental toxicity of styrene has been studied in animals and humans. mating behaviour and fertility), gestation length, litter data (number of pups, sex ratio), postnatal survival, sperm evaluations and primordial follicle counts were not adversely affected by styrene exposure across the generations. styrene reproductive toxicity. 65 Components This product does not contain any chemicals known to State of California to cause cancer, birth defects, or any other reproductive … Styrene 100- 42 -5 90 - 100% Yes 3. Reports of organ toxicity upon chronic exposure to styrene are rare; however, since the chief intermediate in styrene metabolism is an epoxide, hepatotoxicity due to covalent binding at the site of formation appears to be a possibility. There are good reasons that the reduction in grip strength is not an indication for a specific developmental effect but is rather attributable to a combination of reduced body weight and chance variations in data. 1984; NIOSH 1983). Styrene: Can it be used ... or other reproductive harm” by maintaining and updating a list of chemicals “known in the state of California to cause cancer or reproductive toxicity” and also to provide warnings to consumers who may come into contact with products that contain the listed chemicals. Detailed results of these studies are available from the National Institute for Occupational Safety 3 Page Numbers. Reproductive Toxicity… Maternal toxicity, increased preimplantation loss of fetuses, reduced fetal weight, and The characteristic unpleasant smell and low odour threshold (0.1 ppm; 0.43 mg/m3) allows styrene to be readily detected in the workplace at levels below the occupational exposure standards. known effects of inhalation exposure of humans and animals to styrene. Experiments were performed to evalute reproductive and developmental toxicology in rats and rabbits exposed to styrene oxide by inhalation. Reproductive performance (i.e. This study was conducted to evaluate the potential adverse effects of styrene on reproductive capability from whole‐body inhalation exposure of F 0 and F 1 parental animals. Toluene is also used as a solvent for paints, lacquers, and adhesives. Suspected human reproductive toxicant Specific target organ toxicity - single exposure No data available Specific target organ toxicity - repeated exposure Causes damage to organs through prolonged or repeated exposure. FLAMMABLE LIQUID AND VAPOR. Developmental or reproductive toxicity studies have been conducted in rats, mice, rabbits, and hamsters. 2) Information on endocrine system and reproductive system (1) in vitro test results related to receptor binding (Attachment-3) Hazards Identification Emergency Overview ----- DANGER! An LC The acute toxicity of styrene appears to be unrelated to its biotransformation. Reproductive Toxicity Risk Assessment Published on October 31, 1996, Federal Register 61(212):56274-56322 These guidelines replace two proposed guidelines: Proposed Guidelines for Female Reproductive Risk and Proposed Guidelines for Male Reproductive Risk, both dated June 30, 1988. styrene oxide, a finding suggesting preimplantation loss. Styrene NAC: 02/2008 vii repeated exposure of rats through gestation day 6 – 20 to 300 ppm, an increased neonatal death rate and delayed postnatal development was observed compared to … Chronic toxicity and three-generation reproduction study of styrene monomer in the drinking water of rats Maternal toxicity and increased fetal mortality have been observed in rats and rabbits exposed to styrene oxide by inhalation. Possible Reproductive Toxicity of Styrene in Peripubertal Male Mice. Reproductive Toxicity Category 2 Specific target organ toxicity (single exposure) Category 3 Target Organs - Respiratory system. Health and Safety Code section 25249.8(a) requires that substances identified in Labor Code section 6382(d) as causing reproductive toxicity be included on the Proposition 65 list. Styrene-butadiene copolymer 9003-55-8 New Jersey Right to Know Components Styrene-butadiene copolymer 9003-55-8 California Prop. 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